The Latest in GLP-1 Therapy

By Kristen Rider, BSN, RN, CDE

GLP-1 agonist medications are a common treatment for the management of Type 2 Diabetes. They work like the hormone GLP-1 (Glucagon-like peptide 1) that the body normally produces to help regulate blood glucose levels. People with Type 2 Diabetes may be deficient in GLP-1, which is why these medications are being used. GLP-1 agonists work to control blood glucose levels by decreasing the amount of glucose that the liver produces, delaying gastric emptying time, and helping the pancreas to produce more insulin when blood glucose levels are high. The first to hit the market was Byetta in 2005. Since then, several others have been launched, some within the past few months. All of the GLP-1 agonist medications are injectable, but each has a different device or mechanism for injection. Dosing varies from twice daily, daily, to once weekly. Some of these medications are FDA approved for use in conjunction with basal insulin, while others were not studied as such. See the comparison chart below for more information on GLP-1 agonists.

Drug Dose Mixing

Required

Pre-injection waiting time

Dosing

Approved for use with basal insulin

Byetta

Twice daily

No

No

5mcg, 10mcg

Yes
 

Bydureon Kit

 

Once weekly Yes No

2 mg

No
Bydureon Pen
Once weekly Yes No 2 mg

No

Tanzeum

Once weekly

Yes

Yes 15 min

30mg       50mg

Yes

 

Trulicity

Once weekly

No

No  

0.75 mg

1.5mg

No

Victoza  

Once daily

No No 0.6mg

1.2mg

1.8 mg

Yes

Package Insert (PI) list

Byetta (exenatide) AZ – http://www.azpicentral.com/byetta/pi_byetta.pdf#page=1 Bydureon Pen and Kit (exenatide extended release) AZ – http://www.azpicentral.com/bydureon/pi_bydureon.pdf#page=1 Tanzeum (albiglutide) GSK – http://www.gsksource.com/gskprm/htdocs/documents/TANZEUM-PI-MG-IFU-COMBINED.PDF Trulicity (dulaglutide) LILLY – http://pi.lilly.com/us/trulicity-uspi.pdf Victoza (liraglutide NOVO – http://www.novo-pi.com/victoza.pdf

This information is not meant to replace your healthcare Provider’s advice. It is not an endorsement of these products or of the pharmaceutical companies. The Outpatient Diabetes and Nutrition Services Department at St. Anthony’s Medical Center can assist you with questions you may have regarding this change or other questions you have regarding your diabetes self-management. Call us at 314-525-4523 for more information.

Sources:

www.diabetesincontrol.com

www.victozapro.com

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